Britton Chance (1913-2010) was a biochemist and biophysicist as well as a pioneer in the field of biomedical optics. Chance received his Ph.D. in Physical Chemistry from the University of Pennsylvania in 1940 and his Ph.D. in Biology and Physiology from Cambridge University in 1942. Over the course of his nearly eight decade career, Chance was dedicated to the application and transfer of basic scientific research and technology to clinical medicine. The Britton Chance Papers contain correspondence, research notes, experimental data, publication materials, and photographs stemming from Chance's life as a biochemist, biophysicist, and yachtsman. The collection is broken up into fifteen series that document every aspect of his scientific work.

Between 1968 and 1978, the historian of science Horace Freeland Judson conducted extensive oral history interviews with biochemists and molecular biologists relating to the development of their field. The correspondence, transcripts of interviews, and taped interviews that comprise the Judson collection formed the research material used by Judson in his book, The Eighth Day of Creation (New York, 1979). Permission to quote must be obtained from Dr. Judson and access to some files is restricted.